HORIBA Worldwide

Whether the goal is qualitative or qualitative data, Raman analysis can provide key information, easily and quickly, detailing the chemical composition and the structure of the investigated material.

 

For a full list of applications, application notes and analytical illustrations see our Raman applications pages.

1. Pharmaceuticals & Cosmetics Compound distribution in tablets, high throughput screening, raw material verification, polymorphism, crystalline phases, contamination, combinatorial chemistry, biodegradable polymers. True confocal mapping performances of the LabRAM family enable the highest definition and resolution images to be produced. To the right we see a fast Raman map of pharmaceutical crystals: 500 ms/point acquisition.

2. Semiconductors Stress, contamination, superlattice structure and defect investigations, hetero-structures, doping effects, super conductors, photoluminescence... Combining both visible and UV Raman measurements enables a complete characterization of SiGe based devices (shown left). The UV Raman spectrum will characterize only the top layer whereas the spectrum measured in the visible will show the Raman modes characteristic of SiGe.

3. Resonance Raman- Nanotubes SWCNT, Clusters, SERS, Proteins, bio-molecules, LB films... Samples such as carbon nanotubes and bio-molecules can benefit from using the best tuneable sources and filters to match resonance conditions. Combined with confocal Raman mapping structural variations and distribution maps can be generated on samples such as SWCNT (single walled carbon nanotube) islands.

4. Geology/Mineralogy/Gemology Fluid inclusions, gemstones, phase transitions, mineral behavior under extreme conditions, mineral structures, HPT and chemical processing... (Left) High resolution Raman mapped image of a mineral sample, showing Metamictisation of ZrSiO4 by self irradiation due to radioactive decay of Uranium and Thorium incorporated in zircon crystals. This causes damage to the zircon structure leading to amorphous and isotropic (metamict) forms. (Data courtesy of Dr L Nasdala, University of Mainz, Germany

5. Life Science Bio-compatibility, DNA analysis, drug/cell interaction, photodynamic therapy, immunoglobins, nucleic acids, chromosomes, oligosaccharides, cholesterol, lipids, cancer tissue, metabolic accretions, inclusion of foreign materials and pathology... (Right) Micrograph of lumen side of aorta showing fatty and proteinaceous regions with the corresponding Raman map, color-coded with green as protein and red as lipid.

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